In genetics, chromosome translocation is a phenomenon that results in unusual rearrangement of chromosomes. This includes balanced and unbalanced translocation, with two main types: reciprocal , and Robertsonian translocation.

2024年12月2日 · Translocations, in genetics, happen when chromosomes break and the pieces attach to other chromosomes. This mixing of genetic material has important results. The resultant chromosomes are...

Chromosomal translocations are the products of an illegitimate proximity-based repair of DNA double-strand breaks (DSBs), where the proximity of DNA ends from different non-homologous chromosomes can result in their erroneous joining.

2025年1月29日 · A translocation, as related to genetics, occurs when a chromosome breaks and the (typically two) fragmented pieces re-attach to different chromosomes. The detection of chromosomal translocations can be important for the diagnosis of …

We discuss here how broken chromosomes move, how they find their translocation partners, and how they synapse and then join to form translocations. We also discuss the role of spatial genome organization, DNA repair pathways and the epigenetic landscape in this process.

Translocations arise when an end of one chromosome break is mistakenly joined to an end from a different chromosome break. Since translocations can lead to developmental disease and cancer, it is important to understand the mechanisms leading these chromosome rearrangements.

A chromosomal translocation is a type of chromosomal abnormality resulting in fusion of two non-homologous chromosomes. There are two types of translocations, reciprocal and non-reciprocal translocations.

Translocations generate novel chromosomes. In a translocation, a segment from one chromosome is transferred to a nonhomologous chromosome or to a new site on the same chromosome....

2014年4月1日 · A chromosome translocation is defined as a genome abnormality in which a chromosome breaks and either the whole or a portion of it reattaches to a different chromosome (Fig. 1a).

2021年6月8日 · Translocations arise when an end of one chromosome break is mistakenly joined to an end from a different chromosome break. Since translocations can lead to developmental disease and cancer, it...