In genetics, an enhancer is a short (50–1500 bp) region of DNA that can be bound by proteins (activators) to increase the likelihood that transcription of a particular gene will occur. [1][2] These proteins are usually referred to as transcription factors. Enhancers are cis -acting.

Enhancers are classically defined as cis-acting DNA sequences that can increase the transcription of genes. They generally function independently of orientation and at various distances from their target promoter (or promoters).

2024年10月25日 · Enhancers are short DNA sequences, typically ranging from 50 to 1,500 base pairs (bp), that can significantly increase the probability of gene transcription.

2024年11月23日 · When a DNA -bending protein binds to the enhancer, the shape of the DNA changes, which allows interactions between the activators and transcription factors to occur. Repressors respond to external stimuli to prevent the binding of activating transcription factors.

2014年3月11日 · Enhancers are DNA elements that are key regulators of gene expression, but their complexities and context dependence makes their identification and characterization challenging.

2021年12月16日 · When a DNA -bending protein binds to the enhancer, the shape of the DNA changes, which allows interactions between the activators and transcription factors to occur. Repressors respond to external stimuli to prevent the binding of activating transcription factors.

A regulatory DNA sequence that, when bound by specific proteins called transcription factors, enhances the transcription of an associated gene.

Enhancers are cis-regulatory elements containing short DNA sequences that serve as binding sites for pioneer/regulatory transcription factors, thus orchestrating the regulation of genes critical for lineage determination.

(A) An enhancer is a DNA sequence that stimulates gene expression from distance which is characterized by the presence of diverse DNA binding motifs for tissue specific transcription factors (TFs). (B) Left: enhancers form DNA loop mediated by CTCF and cohesins proteins to stimulate gene expression.

3 天之前 · The 3D looping of DNA brings enhancers and the promoters of their target genes into contact. To switch a gene on, the enhancer also needs to become ‘activated’ through acquiring specific chemical modifications and recruiting various proteins. However, it remains unclear whether the looping of enhancers and their activation are regulated ...