A road trip along US-50 follows time from colonial-era landscapes through the Wild West to high-tech Silicon Valley, the best route for the unhurried.

Road trip along the US-50 byway in Nevada from Lake Tahoe to Great Basin National Park and learn why its dubbed The Loneliest Road.

Find the best stops as you drive east through Colorado's rocky mountain scenery on the Loneliest Road in America. Cross-Country Adventures on America's Two-Lane Highways Guides

Learn about the main sights, stops, and towns for road trippers following US-50, the Loneliest Road in America, through southern Illinois.

From Kansas City, and its noteworthy neighboring towns of Independence and Liberty, US-50 makes a lazy trek across Missouri’s rolling-prairie farmlands, stopping at the historic railroad town of Sedalia before reaching the state capital, Jefferson City, roughly midway across.

Continuing east, US-50 winds through endless tracts of pine forest before cresting the Sierra to reach alpine Lake Tahoe, a year-round resort lying astride the California-Nevada border. Map of the Loneliest Road through California. Related Travel Guides

In its 450 mi (725 km) across Kansas, US-50 and its selected variants pass across the agricultural heartland of America, winding through dozens of small farming towns that dot the generally level landscape.

Plan your road trip stops along the Loneliest Road through Indiana, exploring historical sites and Larry Bird's hometown of French Lick.

With a fold-out souvenir map and the top 50 road trips across the U.S., this handsome travel guide offers strategic lists and routes organized by region. Choose from lists of the best coastal drives, cross-country journeys, trips for kids, awe-inspiring views, and more.

For most of the way across Utah, the high-speed I-70 freeway has replaced US-50, but if you have time to take a couple of detours, you’ll be rewarded with some of the most incredible scenery in the world.