To restrict the loss of gene expression in knockout mice in time or location with the body, a binary system of unique strains of mice are developed that utilizes both ES cell-derived genetic …

Transgenic organisms generated by pronuclear microinjection typically over‐express the transgene, whereas animals generated by gene targeting are characterized by the deletion or …

The most important candidate gene for generating GH-transgenic farm animals to increase the growth rate and milk production [2 – 4] is growth hormone. Myostatin is a negative regulator of …

1 天前 · Cas12a represents the next generation of gene editing. Here, the authors present the generation and validation of a Cas12a transgenic mouse model. Additionally, the authors …

2020年1月1日 · Here, we review the genetic, transgenic, and viral techniques that are currently available to probe the complex relationship between genes and cognition. Topics covered …

They have systematically "knocked out" a set of genes in mice, called homeotic genes, which govern body patterning during development. For example, one of the lab's most recent genetic …

CRISPR /Cas9 is a powerful technology that has transformed gene editing of mammalian genomes, being faster and more cost-effective than standard gene targeting techniques. In …

2025年1月22日 · In vitro results showed that the TKD of three genes (PSGL1, CD11a, and CD49d) decreased CAR-T cell transendothelial migration and adhesion to endothelial cells …

3 天之前 · In the present study, we applied CRISPR/Cas9 gene editing technology to knock out the two IgM genes in Atlantic salmon. High-throughput sequencing was used to assess the …

2014年8月19日 · Targeted gene knockout by editing specific loci in genome has revolutionized the field of functional genomics. Transcription activator-like effector nucleases (TALENs) are …