A knockout mouse, or knock-out mouse, is a genetically modified mouse (Mus musculus) in which researchers have inactivated, or "knocked out", an existing gene by replacing it or disrupting it with an artificial piece of DNA.

2020年8月17日 · A knockout mouse is a laboratory mouse in which researchers have inactivated, or "knocked out," an existing gene by replacing it or disrupting it with an artificial piece of DNA. What are knockout mice used for?

基因敲除小鼠（knockout mouse）是80年代后半期应用DNA同源重组原理发展起来的动物实验，其实小鼠有很多种，小白鼠只是其中一种，通常普通的小白鼠多被药厂用作临床试验，而基因敲除的小鼠，则用于更尖端的生物医学研究。

Scientists around the world are working to generate a targeted knockout mutation for every gene in the mouse genome through the Knockout Mouse Project (KOMP) which is providing critical tools for understanding gene function and the genetic causes of human diseases.

Through a combination of gene targeting and gene trapping, a global effort is underway to make a knockout mouse for all of the 25,000 mouse genes (Grimm, 2006). The knockout mouse has been a valuable tool for geneticists to discern the role of a gene in embryonic development and in normal physiological homeostasis.

Knockout mouse, genetically engineered laboratory mouse (Mus musculus) in which a specific gene has been inactivated, or “knocked out,” by the introduction of a foreign (artificial) DNA sequence. Knockout mice exhibit modifications in phenotype (observable traits) and thereby provide important

2021年4月2日 · What is a Knockout Mouse? A knockout (KO) mouse is a genetically engineered animal model in which certain genes or DNA sequences have been deleted, thus achieving a nonfunctional gene which provides insights on its function. Investigating gene knockout mice characteristics can help scientists have a better understanding of gene functions and ...

2012年6月15日 · The Knockout Mouse Project (KOMP) is a trans-National Institutes of Health (NIH) initiative that aims to generate a comprehensive and public resource comprised of mice containing a null mutation in every gene in the mouse genome. (See: The NIH Knockout Mouse Project Website [nih.gov])

A knockout mouse is a laboratory mouse in which one or more genes have been turned off or "knocked out." To create a knockout mouse, scientists genetically engineer the...

2004年9月1日 · Mouse knockout technology provides a powerful means of elucidating gene function in vivo, and a publicly available genome-wide collection of mouse knockouts would be significantly enabling...