To determine how astrocytic leptin signaling regulates the physiological response of mice to diet-induced obesity (DIO), we performed metabolic analyses and hypothalamic leptin signaling …

2019年3月1日 · We generated complementary lines of mice with either leptin receptor (Lepr) knockdown or reconstitution in adipose tissues using Cre-lox methodology. Lepr knockdown …

Here, we report the creation and characterization of the first Lep knockout rat via pronuclear microinjection of ZFNs. The Lep knockout rat, designated as LepΔ151/Δ151, is obese, …

2024年1月1日 · To investigate whether FTO affects leptin-STAT3 signaling, contributing to HFD-induced obesity, we generated mice with Fto knockout in leptin receptor-expressing …

2020年8月3日 · To assess Lepr function in Shh signaling, we generated a Lepr conditional knockout (cKO) mouse line by crossing Shh-Cre with Leprflox/flox tg mice. We assessed …

2021年1月1日 · The leptin receptor (Lepr) pathway is important for food intake regulation, energy expenditure, and body weight. Mutations in leptin and the Lepr have been shown to cause …

2020年8月3日 · Conditional knockout of leptin receptor in neural stem cells leads to obesity in mice and affects neuronal differentiation in the hypothalamus early after birth

2023年6月5日 · Male and female T cell-specific leptin receptor knockout mice and littermate controls were placed on low-fat diet or high-fat diet to induce obesity for 18 weeks. Weight …

2022年3月25日 · Here, conditional leptin receptor knockout (Lepr cKO) with a progesterone receptor-driven Cre recombinase was used to examine the importance of leptin signaling in …

2007年8月10日 · Liver-specific insulin receptor knock-out (LIRKO) mice display hyperinsulinemia, abnormal glucose metabolism, and progressive liver dysfunction. In addition, circulating leptin …