2021年6月21日 · Parkinsonism caused by antipsychotic (neuroleptic) medication is sometimes referred to as neuroleptic-induced parkinsonism. The types of medications most likely to have this effect include some...

2012年8月1日 · Typical antipsychotics, also known as neuroleptics, are the most common causes of DIP. However, atypical antipsychotics, which were thought to be free from EPS, can also induce parkinsonism.

The diagnosis of drug-induced parkinsonism is important to recognize, as the syndrome is reversible when the offending medication is removed. This topic reviews the causes, clinical features, diagnosis, and treatment of drug-induced parkinsonism.

Neuroleptics can unmask preclinical PD in patients with insufficient SN damage for the disease to manifest clinically. Though the mechanism of sustained parkinsonian features after discontinuing neuroleptics remains to be established, it is unlikely that dopamine receptor block leads to retrograde SN neuronal degeneration.

Up to 20% of older adults may suffer from persisting parkinsonism months after discontinuation of antipsychotics, suggesting underlying neurodegeneration. A review of the literature on AIP in older adults is presented, focusing on epidemiology, clinical aspects, and management.

2008年2月19日 · The most common culprits are the neuroleptics with potent dopamine D2-receptor blocking actions, including haloperidol and perphenazine. 1 If chronic neuroleptic drug use is required, the lowest effective dose or an atypical neuroleptic drug is preferred.

Twenty six consecutive patients with neuroleptic-induced Parkinson's syndrome (NIPS) are described. Their median age was 61 years, 60% were female, and most had received chronic neuroleptic medication for psychiatric indications.

2008年2月19日 · The most common culprits are the neurolep-tics with potent dopamine D2-receptor blocking actions, including haloperidol and perphenazine.1 If chronic neuroleptic drug use is required, the lowest effective dose or an atypical neuroleptic drug is preferred.

Although Parkinson's disease can occur in individuals with psychosis, a patient on antipsychotic medication who develops parkinsonian signs may more readily be diagnosed as and treated for neuroleptic-induced parkinsonism.

2015年12月11日 · Neuroleptics can unmask preclinical PD in patients with insufficient SN damage for the disease to manifest clinically. Though the mechanism of sustained parkinsonian features after discontinuing neuroleptics remains to be established, it is unlikely that dopamine receptor block leads to retrograde SN neuronal degeneration.