Three important concepts have emerged from the recent literature on neuronal cell death: 1) that there are many ways in which a neuron may die, 2) that there exists extensive cross-talk (and at times ambiguity) between various modes of cell death, and 3) that neuronal cell death is not merely a ‟cell autonomousˮ event but it is often aided ...

2018年4月1日 · We review here the mechanisms of neuronal death by intrinsic and extrinsic apoptosis, oncosis, necroptosis, parthanatos, ferroptosis, sarmoptosis, autophagic cell death, autosis, autolysis, paraptosis, pyroptosis, phagoptosis, and mitochondrial permeability transition.

2018年2月28日 · We review here the mechanisms of neuronal death by intrinsic and extrinsic apoptosis, oncosis, necroptosis, parthanatos, ferroptosis, sarmoptosis, autophagic cell death, autosis, autolysis, paraptosis, pyroptosis, phagoptosis, and mitochondrial permeability transition.

Neuronal cell death is a core feature of both acute central nervous system (CNS) insults (e.g. stroke and trauma) and several neurodegenerative disorders, including Alzheimer's, Parkinson's (PD) and Huntington's diseases. Cell replacement therapy, therefore, is potentially an attractive strategy in these conditions.

In this review, we will briefly go through the general pathways of cell death and describe evidence for cell death in the context of individual common neurodegenerative diseases, discussing our current understanding of cell death by connecting with renowned pathogenic proteins, including Tau, amyloid-beta, alpha-synuclein, huntingtin and TDP-43.

This review describes the main mechanisms of neuronal cell death, particularly apoptosis, necrosis, excitotoxicity and autophagic cell death, and their role in neurodegenerative diseases such as ischaemia, Alzheimer's, Parkinson's and Huntington's diseases.

1998年4月1日 · Several authors have proposed explanations for the generality of neuronal cell death, based on correction of erroneous projections, creation of pathways for axon outgrowth, numerical limitations imposed by mechanisms involving successive cell doubling, transient functions for the eliminated neurons, etc. (reviewed by 112, 10).

A better understanding of the molecular mechanisms of neuronal cell death in nervous system development, injury and disease can lead to new therapeutic approaches for the prevention of neurodegeneration and neurological disabilities and will expand the field of cell death biology.

2021年6月7日 · While removal of superfluous neuronal cells is vital for normal brain function, aberrant death of distinct neuronal cell populations is a hallmark of pathology associated with...

Neuronal loss occurs as an essential feature of normal CNS development, as well as in acute or chronic neurodegenerative disorders. 1 – 4 It has long been recognized that a variety of factors can trigger secondary auto-destructive reactions within the CNS, including free radicals, excitatory amino acids, eicosanoids, lipid degradation products, ...