Concerning forms of neuronal death, the consensus is that in the central core of the ischemic area, cell death is oncotic/necrotic, sometimes is called pan-necrosis, indicating that all types of cells, neurons, astroglia, and endothelial cells die in this severely injured zone.

Neuronal death refers to the natural process of cell death in neurons during normal nervous system development, influenced by interactions with trophic substances and hormones to ensure proper neural connections and tissue remodeling.

This review describes the main mechanisms of neuronal cell death, particularly apoptosis, necrosis, excitotoxicity and autophagic cell death, and their role in neurodegenerative diseases such as ischaemia, Alzheimer's, Parkinson's and Huntington's diseases.

2018年4月1日 · We review here the mechanisms of neuronal death by intrinsic and extrinsic apoptosis, oncosis, necroptosis, parthanatos, ferroptosis, sarmoptosis, autophagic cell death, autosis, autolysis, paraptosis, pyroptosis, phagoptosis, and mitochondrial permeability transition.

Autopsy findings of AD reveal massive neuronal death manifested in the form of cortical volume shrinkage, reduction in sizes of gyri to up to 50% and an increase in the sizes of sulci. Multiple forms of cell death have been recorded in neurons from different studies conducted so far.

2018年2月28日 · We review here the mechanisms of neuronal death by intrinsic and extrinsic apoptosis, oncosis, necroptosis, parthanatos, ferroptosis, sarmoptosis, autophagic cell death, autosis, autolysis, paraptosis, pyroptosis, phagoptosis, and mitochondrial permeability transition.

During development, programmed cell death via apoptosis assures that appropriate matches exist between neurons and their target cells. Nuclear changes are late events and the first steps leading toward developmental neuronal death typically occur in …

Taken together, regulatory mechanisms that control expression of key apoptotic and necrotic genes during brain development appear to predetermine different types of injury-induced neuronal death.

2008年10月10日 · We illustrate the current understanding of neuronal death employing two diseases of neuronal loss, AD (Alzheimer’s disease), which is the most common chronic neurodegenerative disorder, and cerebral ischaemia/stroke, the third most common cause of death in the Western world, which is an acute neuronal disorder with chronic sequelae.

A better understanding of the molecular mechanisms of neuronal cell death in nervous system development, injury and disease can lead to new therapeutic approaches for the prevention of neurodegeneration and neurological disabilities and will expand the field of cell death biology.