2021年1月6日 · In mice with a progeria-causing mutation, a cousin of the celebrated genome editor known as CRISPR corrected the DNA mistake, preventing the heart damage typical of the disease, a research team reports today in Nature. Treated mice lived about 500 days, more than twice as long as untreated animals.

2021年1月6日 · Although CRISPR–Cas9-mediated genetic disruption of the pathogenic allele has been reported to improve phenotypes in mouse models of progeria 15,16,17, the resulting diversity of...

2019年2月18日 · Here we show that reduction of lamin A/progerin by a single-dose systemic administration of adeno-associated virus-delivered CRISPR–Cas9 components suppresses HGPS in a mouse model. Laminopathies...

Here we show that reduction of lamin A/progerin by a single dose systemic administration of AAV-delivered CRISPR/Cas9 components suppresses HGPS in a mouse model. Laminopathies are degenerative disorders caused by mutations that affect proteins in the nuclear lamina 1.

2021年1月6日 · Researchers have successfully used a DNA-editing technique to extend the lifespan of mice with the genetic variation associated with progeria, a rare genetic disease that causes extreme premature aging in children and can significantly shorten their life expectancy.

Here we show that reduction of lamin A/progerin by a single-dose systemic administration of adeno-associated virus-delivered CRISPR-Cas9 components suppresses HGPS in a mouse model. Hutchinson-Gilford progeria syndrome (HGPS) is a rare lethal genetic disorder characterized by symptoms reminiscent of accelerated aging.

2021年4月16日 · A recent paper published in Nature by Koblan et al. reported the use of CRISPR-mediated adenine base editor (ABE) to repair mutations of the Hutchinson–Gilford progeria syndrome (HGPS or...

2019年2月19日 · Researchers have developed a new gene therapy to help decelerate the aging process. The findings highlight a novel CRISPR/Cas9 genome-editing therapy that can suppress the accelerated aging...

2021年1月6日 · The CRISPR gene-editing therapy more than doubled the lifespan in a mouse model by tackling the root cause of Hutchinson-Gilford progeria. The new research raises the hope for future therapy of the devastating disease for which no cure currently exists.

2021年1月6日 · CRISPR gene editing has been used to more than double the lifespan of mice engineered to have the premature ageing disease progeria, also greatly improving their health. The results far...