T-cell receptor α- and β-chain gene rearrangement and expression. The TCRα- and β-chain genes are composed of discrete segments that are joined by somatic recombination during development of the T cell.

The four T cell receptor genes (Tcra, Tcrb, Tcrg, Tcrd) are assembled by V (D)J recombination according to distinct programs during intrathymic T cell development.

T-cell receptor (TCR) gene rearrangement is a marker of clonality and may be used to detect early progression in the blood. 1 - 3 This gene rearrangement is a regulated process in T-cell development enabling recognition of specific antigens. 4 In CTCL, malignant T-lymphocytes share identical TCR gene rearrangements, making TCR assessment in ...

T cell receptor (TCR) gene rearrangement is an important event in T cell ontogeny that enables T cells to recognise antigens specifically, and any dysregulation in this complex yet highly regulated process may result in disease.

2020年9月22日 · T-cell receptor gene rearrangement testing detects characteristic changes in specific genes in T-cells to help diagnose a T-cell lymphoma.

Key Concepts and Summary The TCR is similar in structure to immunoglobulins, but less complex. Millions of unique epitope-binding TCRs are encoded through a process of genetic rearrangement of V, D, and J gene segments.

T-cell receptor (TCR) gene rearrangement is an important event in T-cell ontogeny that enables T cells to recognize antigens specifically. From: Self-Assessment Questions for Clinical Molecular Genetics, 2019

Most T-lymphocytes express a highly specific antigen receptor (TCR) on their cell surface, consisting of a clonotypic αβ-heterodimer. Both α- and β chains are products of somatic rearrangements of V, (D) and J gene segments encoded on the respective loci.

TCR development in the thymus is critical for development of a functional immune system. The gene rearrangement of a TCR involves the selection of immature T cells in the thymus maturing to become functional T cells that recognize foreign molecules and respond to them appropriately.

The T-cell receptor (TCR) genes (alpha, beta, delta, and gamma) are comprised of numerous, discontinuous coding segments that somatically rearrange to produce heterodimeric cell surface T-cell receptors, either alpha/beta (90%-95% of T cells) or gamma/delta (5%-10% of T cells).