Tumor necrosis factor alpha (TNF-α) is a cytokine that has pleiotropic effects on various cell types. It has been identified as a major regulator of inflammatory responses and is known to be involved in the pathogenesis of some inflammatory and autoimmune diseases [1].

Tumor necrosis factor (TNF), formerly known as TNF-α, is a chemical messenger produced by the immune system that induces inflammation. [5] TNF is produced primarily by activated macrophages, and induces inflammation by binding to its receptors on other cells. [6]

2023年11月14日 · Your system gets flooded with inflammation, which often means you have too much tumor necrosis factor – specifically, a type called TNF alpha. You can think of the white blood cells that make...

2021年3月8日 · Tumor necrosis factor alpha (TNF-α) was initially recognized as a factor that causes the necrosis of tumors, but it has been recently identified to have additional important functions as a pathological component of autoimmune diseases.

Tumor necrosis factor (TNF) is a critical cytokine, which contributes to both physiological and pathological processes. This mini-review will briefly touch the history of TNF discovery, its family members and its biological and pathological functions.

Tumor necrosis factor alpha (TNF-α) is a proinflammatory cytokine that exerts both homeostatic and pathophysiological roles in the central nervous system. In pathological conditions, microglia release large amounts of TNF-α; this de novo production ...

Tumor necrosis factor alpha (TNF, TNFSF2) is the prototypical member of a large superfamily of at least 17 related cytokines that play key roles in regulating inflammation, host defense, adaptive immunity, apoptosis, autoimmunity, and organ development.

Tumor Necrosis Factor-alpha (TNF-α) is a prototypic pro-inflammatory cytokine involved in the innate immune response. TNF-α ligation and downstream signaling with one of its cognate receptors, TNF-RI or TNF-RII, modulates fundamental processes in the brain including synapse formation and regulation, …

Tumor necrosis factor alpha (TNF-α) is a cytokine mainly secreted by macrophages that is implicated in immune response regulation and is essential in driving major cellular changes by activating different signaling cascades.

Tumor necrosis factor alpha (TNFα; in this chapter shortened to TNF) is a member of the TNF superfamily of cytokines and their receptors and shows many biological functions of potential importance in inflammation, including effects on vascular biology, immune and …