Coordination of the AMPK, Akt, mTOR, and p53 Pathways under …
AMPK acts as a sensor of cellular energy status and transmits the stress signal by phosphorylating p53, TSC2, IRS-1, and TXNIP. Activated p53 at moderate levels cooperates …
Computational modeling of AMPK and mTOR crosstalk in
2023年7月17日 · Here, we develop a computational model of synaptic signaling resulting in the activation of two protein kinases critical in metabolic regulation and cell fate, AMP-Activated …
AMPK and Akt/mTOR signalling pathways participate in glucose …
The low glucose concentration at 5 mM significantly promoted HBV replication via enhanced transcription and autophagy when compared with higher glucose concentrations (10 and 25 …
Coordination of the AMPK, Akt, mTOR, and p53 Pathways under …
2022年11月29日 · We propose a minimal network model for the cellular response to glucose restriction, characterizing the glucose uptake and signaling of the AMPK, Akt, mTOR, and p53 …
mTOR/AMPK signaling in the brain: Cell metabolism, proteostasis …
The mechanistic (or mammalian) target of rapamycin (mTOR) and the adenosine monophosphate-activated protein kinase (AMPK) regulate cell survival and metabolism in …
A systems study reveals concurrent activation of AMPK and mTOR ... - Nature
2016年11月21日 · We report that AMP-activated protein kinase (AMPK), phosphatidylinositide 3-kinase (PI3K) and mTOR complex 2 (mTORC2) are acutely activated by aa-readdition in an …
AMPK directly activates mTORC2 to promote cell survival
AMP-activated protein kinase (AMPK) senses energetic stress and, in turn, promotes catabolic and suppresses anabolic metabolism coordinately to restore energy balance. We found that a …
Differential Changes in Akt and AMPK Phosphorylation Regulating mTOR …
By analyzing placental samples from pregnant women with different phenotypes of fetal growth and using primary cytotrophoblast to test the effects of OGD and increasing glucose …
Editorial: AMPK and mTOR Beyond Signaling: Emerging Roles in ...
2021年1月14日 · The AMPK and mTOR signaling pathways are emerging as major players that integrate several cellular processes in the reproductive system and embryonic development. In …
图说AMPK及其信号通路的功能 - 知乎 - 知乎专栏
2018年8月9日 · ampk作为调控能量稳态的重要激酶，是真核生物细胞和有机体代谢的中心调节剂之一，负责监管细胞的能力输入和输出，维持细胞生理活动的平稳运转。 同时，AMPK也是一 …