T-cell surface glycoprotein CD3 zeta chain also known as T-cell receptor T3 zeta chain or CD247 (Cluster of Differentiation 247) is a protein that in humans is encoded by the CD247 gene. [5] …

Phosphorylation of the ITAM on CD3 renders the CD3 chain capable of binding an enzyme called ZAP70 (zeta associated protein), a kinase that is important in the signaling cascade of the T cell.

CD3 eta and CD3 zeta are alternatively spliced products of a common genetic locus and are transcriptionally and/or post-transcriptionally regulated during T-cell development.

2024年12月24日 · The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and …

Know comprehensive CD3 zeta/CD247 protein information including protein sequence, molecular weight, theoretical pI, structure, function and protein interaction.

2022年10月3日 · The CD3 zeta component is critical for initiating T-cell activation and anti-tumor activity, while 4-1BB enhances the expansion and persistence of tisagenlecleucel. Upon …

Here we show that mice utilizing a single ITAM sequence (γ, ε, δ, ζa, ζb or ζc) at each of the 10 ITAM locations exhibit a substantial reduction in thymic cellularity and limited CD4 − CD8 − …

In this study, we used a series of immunoreceptor tyrosine-based activation motif (ITAM)-mutant and transmembrane-modified receptors to demonstrate that CARs activate T cells both directly …

2002年10月10日 · CD3Z ITAMs phosphorylation creates multiple docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active …

2006年5月4日 · Cases of severe combined immunodeficiency with mutations in the CD3δ or CD3ε genes 13,14 demonstrate the essential role of CD3δ and CD3ε in T-cell differentiation. …