2013年1月9日 · Our study establishes that TALEN-mediated gene targeting is an efficient method for creating heritable null mutations in a specific locus of the mouse genome.

2012年10月1日 · Cytoplasmic injections of TALEN mRNAs into livestock zygotes were capable of inducing gene KO in up to 75% of embryos analyzed, a portion of which harbored biallelic …

Transcription activator-like effector nucleases (TALENs) are used widely for gene targeting in various model animals. Here, we developed a strategy using TALENs to target the GGTA1, …

2017年4月1日 · Our TALEN approach appears to be highly efficient: targeted mutation events were detected in 50% of all transformants obtained, whereas 21% of the transformants were …

2012年10月23日 · Cytoplasmic injections of TALEN mRNAs into livestock zygotes were capable of inducing gene KO in up to 75% of embryos analyzed, a portion of which harbored biallelic …

2016年7月1日 · In this study, an efficient method to increase the enrichment efficiency of TALEN-mediated biallelic knockout (KO) cells was established, and corresponding genetically …

Precise and targeted genome editing using Transcription Activator-Like Effector Endonucleases (TALENs) has been widely used and proven to be an extremely effective and specific …

Our study establishes that TALEN-mediated gene targeting is an efficient in a specific locus of the mouse genome. We also provide evidence that TALEN activity the number produced by the...

TALENs successfully induced nucleotide deletion mutations of ORF shifts, resulting in loss of chicken gene OV function. Our results demonstrate that the TALEN technique used in the …

Knockout mice created by TALEN-mediated gene targeting. Knockout mice created by TALEN-mediated gene targeting Nat Biotechnol. 2013 Jan;31(1):23-4. doi: 10.1038/nbt.2477. Authors …